Thymosin beta 15: a novel regulator of tumor cell motility upregulated in metastatic prostate cancer.

The Dunning rat prostatic carcinoma is a model system where cell motility closely correlates with the metastatic phenotype. We have identified a novel gene, upregulated in the highly motile and metastatic Dunning cancer cell lines, that represents a new member of the thymosin-beta family, thymosin beta 15. Transfection of antisense thymosin beta 15 constructs into rat prostatic carcinoma cells demonstrates that this molecule positively regulates cell motility, a critical component of the metastatic pathway. Thymosin beta 15 levels are elevated in human prostate cancer and correlate positively with the Gleason tumor grade. Thymosin beta 15 may represent a potential new biochemical marker for human prostate cancer progression.

胸腺素β15:一种在转移性前列腺癌中上调的肿瘤细胞运动性的新型调节剂。

Dunning大鼠前列腺癌是一个模型系统，其中细胞运动性与转移表型密切相关。我们已经鉴定了一种新基因，它在高活动性和转移性Dunning癌细胞系中上调，代表胸腺素β家族的一个新成员，胸腺素β15。将反义胸腺素β15构建体转染到大鼠前列腺癌细胞中表明，该分子正调节细胞运动性，细胞运动性是转移途径的关键组成部分。胸腺素β15水平在人前列腺癌中升高，并且与Gleason肿瘤分级正相关。胸腺素β15可能代表人类前列腺癌进展的潜在的新生化标记。