Functional and profiling studies prove that prostate cancer upregulated neuroblastoma thymosin beta is the true human homologue of rat thymosin beta15.

A peptide with a sequence identical to rat thymosin beta(Tb)15 was reported to be upregulated in human prostate cancer. However, in this report we provide evidence that TbNB, initially identified in human neuroblastoma, is the only Tb isoform upregulated in human prostate cancer and that the Tb15 sequence is not present herein. In addition, we demonstrate that human TbNB has a higher affinity for actin in comparison to Tb4 and promotes cell migration. In combination, this experimentally validates TbNB as functional homologue of rat Tb15 in the human organism and clarifies the current composition of the human Tb family.

功能和特征研究证明前列腺癌上调的神经母细胞瘤胸腺素β是大鼠胸腺素β15的真正人类同源物。

据报道，具有与大鼠胸腺素β(Tb)15相同序列的肽在人前列腺癌中上调。然而，在本报告中，我们提供了证据表明，最初在人类神经母细胞瘤中发现的TbNB是唯一在人类前列腺癌中上调的Tb亚型，而Tb15序列在本文中不存在。此外，我们证明，与Tb4相比，人TbNB对肌动蛋白具有更高的亲和力，并促进细胞迁移。总之，这在实验上证实了TbNB是人类机体中大鼠Tb15的功能同源物，并阐明了人类Tb家族的当前组成。